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  Alzheimer's - Brain Death, a Metabolic disease driven by Lifestyle and Diet.


Prof. Michael A. McGerk III | by my Mother - June/2017


Topic: Brain Death |
Part 1: Alzheimer's - a Metabolic Disease

Ref: Dr. Dale E. Bredesen, MD, also The Brain is not a Glucose-dependent Organ | contributor Sep/2017

, as current evidence shows that our brain size increased 350% [Brain] and blood flow to the brain increased 600%, [Brain Energy] clearly indicating our brain's energy requirements. With our large brain using 20% of metabolic energy and more when sleeping (Circadian Rhythm and Time-Restriced Feeding, TRF) our metabolism needed to produce more energy for our complex bodily systems and complex thinking. (Note 1)

In addition, this bodily change to a higher energy requirement and sourcing, allowed for smaller intestines, better immune system, more reproduction, more time for hunting and social contact, and bigger brains. The brain is extremely expensive in metabolic terms, and uses about 20% of food calories. Humans have the biggest brain and the smallest gut among primates. (1,2)

The brain, heart, liver, and kidneys consume about 60% of the body’s energy intake thereby dominating resting human energy metabolism. The heart and kidneys are metabolically more active than the brain but, being larger, the brain takes a higher proportion of the body’s total energy needs, i.e. about 20–23% of the body’s total energy requirement despite representing only 2.0–2.3% of adult body weight (3,4,5). Three major parameters linked to brain energy metabolism – cerebral blood flow, oxygen consumption, glucose and ketone metabolism - can all be measured independently in humans using minimally invasive techniques. (6,7)

Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all modern diseases, i.e. Man-made. Essentially these man-made diseases are all hallmarks of insulin overload manifested as Dr. Raven's Syndrome X. (8,9) Ref: ...

Alzheimer's: | a Metabolic Disease you can cure.

Half of what we know is wrong, the purpose of science is to determine which half " ... Arthur Kornberg, Nobel Laureate - DNA, "The Nobel Prize in Physiology or Medicine 1959"

by some doctors. According to Dr. Georgia Ede - Diagnosis: Diet and Preventing Alzheimer's -, she points out that 80% of Alzheimer's patients have Insulin Resistance - or full blown Type 2 diabetes. Preventing Alzheimer’s disease Is easier than we think as researchers now understand that insulin resistance is a powerful force in the development of Alzheimer’s Disease.

Dr. Ede explains ... It’s more accurate to think of it this way: Insulin resistance of the body is type 2 diabetes; insulin resistance of the brain is type 3 diabetes. They are two separate diseases caused by the same underlying problem: Chronic Insulin Resistance.

Mounting research also suggests Alzheimer’s (Diabetes of the Brain - Type 3) disease is intricately connected to Insulin Resistance; even mild elevation of blood sugar is associated with an elevated risk for dementia (mean age baseline was 76 - higher average glucose levels within the preceding 5 years were related to an increased risk of dementia ). (10) Diabetes and heart disease also elevate your risk, as all three conditions are rooted in Chronic Insulin Resistance. Simply Say NO to Sugar and get your Exercise.

 

 

The brain is made almost entirely of fat (57%) (50% fat by dry weight), and protein (38%), and contains very little carbohydrate (5%). From Dr. Cate Shanahan's book Deep Nutrition we also know that the ratio of Omega-3 to Omega-3 is 1:1 in the Brain, hence dietary shortages or the wrong dietary intake of fats and oils will change our Lipid Profile. Ref: ... this site - Lipids and the Centenarian Diet, and Dr. Cate's recommendations.

grew up in a low glycemic index environment. For 2 million years of our evolution, we ate much less carbohydrate than we do now, and certainly no refined or processed carbohydrates. The brain needs blood sugar and insulin levels to be nice and even in order to keep brain chemistry stable. The Real Rub - we were never designed to use carbs as fuel. Also ref: ... Carb-Loading (debunked).

    Importance/benefits of fat and ketone bodies (Ketosis) in the Brain.

  1. Fat in general makes up approx. 80% of our brain and nervous system. Ref: ... this site
  2. 50% of the body's fat is Saturated Fat. 11% arachidonic acid and 25% of fatty acids making up the brain neurons and cells, are DHA - Omega-3. Ref: ... Fats and Oil - Where did the Omega-3s Go? | contributor april/2016. (11)
  3. - as it has proven false and many elite athletes are now becoming for best results. Just by pure math it can be shown why Carb-loading is wrong and now Carb-loading Debunked Humans and Animals simply cannot store enough due to their Water Absorption Properties, i.e. Hydrophilic.
  4. Ketones are an abundant, stable and steady source of fuel, even in the absence of regular eating. We can store 100Kcal of fat energy as opposed to 2Kcal of carbs. Dr. Hasselbalch showed that a ketogenic state results in a substantial (39%) increase in cerebral blood Flow. [ Hasselbatch SG, et al. 1996]. (12)

Neural Plasticity: | Brain Healing and Growth

the brain has the ability to reorganize itself by forming new neural connections throughout life. Neuroplasticity allows the neurons (nerve cells) in the brain to compensate for injury and disease and to adjust their activities in response to new situations or to changes in their environment.

we are now seeing New Diseases created by malnutrition and excessive intake of carbohydrates, i.e. Excess Carbohydrates is Malnutrition. Chronic Inflammation is leading us into the realm of Type 2 diabetes and Alzheimer's.

Topic: Brain Death | Part 2

TBD, ... but you can read Dr. Dale E. Bredesen's book - The End of Alzheimer's
or Amy Berger's Book- The Alzheimer's Antidote

 

 

  1. With our current understanding of a LCHF lifestyle, i.e. ... the Centenarian Diet, we should be able to prevent Alzheimer's, and control Insulin Resistance and the exponentially growing diseases driven by the SAD. Ref: Exponential Epigenetic Affect - The rise of Man-made Diseases | contributor March/2017. This paradigm shift to a Ketone Fuel will protect the by a shift away from man-made Hyper-Palatable Foods.
  2. Simple solution, avoid carbohydrates as they offer No known nutritional benefits, and there is No known medical deficiency Disease Condition. Carbohydrates are however packaged in food source organisms that do provide Longevity Vitamins, Our foods provide Phytonutrients, macronutrients, micronutrients (for critical DNA repair) (R1), Polyphenols, Phytosterols, Flavonoids, Lignans, Antioxidants, and Carotenoids, that do allow life to continue. Ref: 100 richest dietary sources of polyphenols. (Resource 1,2,3)
  3. Certainly avoid processed carbohydrates, fats and oils, and packaged and processed foods. A direct result of too many carbohydrates is Insulin Resistance functional manifested as Carbohydrate Intolerance. Dr. Volek discusses his current views on the benefits of a LCHF plan - Health-Promoting Effects of a Low-Carbohydrate Lifestyle | july/2016 and this site follows this type of plan with the addition of Dr. Ames' "Triage Theory" ... the Centenarian Diet.

 

 


Notes:

  1. A University of Adelaide-led project has overturned the theory that the evolution of human intelligence was simply related to the size of the brain, but rather linked more closely to the supply of blood to the brain. (20) The blood flow diagram directly correlates to the above brain size diagram. (21) To allow our brain to be so intelligent, it must be constantly fed oxygen and nutrients from the blood. Dr. Snelling and Ms. Bosiocic say ... "Throughout evolution, the advance in our brain function appears to be related to the longer time it takes for us to grow out of childhood. It is also connected to family cooperation in hunting, defending territory and looking after our young".
  2. The light:dark cycle generated by the earth's rotation is the driving force of daily behavioral and physiological rhythms exhibited by most organisms. However, these daily (∼24 hr) rhythms are not just a passive response to the light:dark cycle; instead, an intrinsic timekeeping mechanism synchronizes physiological processes to the cyclic environment. The endogenous timekeeper is a self-sustained oscillator, termed the circadian clock, (20)

 


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[ + ] Sources and References:

  1. R1 PubMed, Effects of micronutrients on DNA repair. Collins AR, Azqueta A, Langie SA.
  2. Resource 1 ECJN, Table 1. Polyphenol and antioxidant content in the 100 richest foods (mg per 100 g or mg per 100 ml)
  3. Resource 2 ECJN, Identification of the 100 richest dietary sources of polyphenols: an application of the Phenol-Explorer database, J Perez-Jimenez, V Neveu, F Vos and A Scalbert
  4. Resource 3 Phenol-Explorer.eu, Phenol-Explorer is the first comprehensive database on polyphenol content in foods
  5. org The Noakes Foundation, Our goal is to support the dietary revolution that will reverse the global epidemics of obesity and type 2 diabetes mellitus (DM).
  6. Rub youTube Nutrition Forum - Dr. Donald Layman, PhD, june/2013.
  7. RubADub Crain Medicine, Ancestral Knowledge for a Modern World, A Spoonful of Sugar Helps the Medicine Go Up! DAVID HASTINGS LLOYD, feb/2015
  8. RubADub-Dub youTube, Eric Westman, MD, MHS -- LCHF Treatment of Diabetes, jul/2015
  9. 1 youTube, Catching Fire: How Cooking Made Us Human, by Dr. Richard Wrangham, Professor at Harvard University
  10. 2 youTube, University of California Television, CARTA: The Evolution of Human Nutrition
  11. 3 NCBI PMC, PMCID: PMC3478067, NIHMSID: NIHMS408033 BRAIN FUEL METABOLISM, AGING AND ALZHEIMER’S DISEASE, SC Cunnane, et al.
  12. 4 NCBI PubMed, PMID: 5551034, Metabolic rate and organ size during growth from infancy to maturity and during late gastation and early infancy. Holliday MA.
  13. 5 PubMed, Neurochem Res. 1999 Feb;24(2):321-9. Energetics of functional activation in neural tissues. Sokoloff L.
  14. 6 PubMed, Trends Neurosci. 2004 Aug;27(8):489-95. Energetic basis of brain activity: implications for neuroimaging. Shulman RG, Rothman DL, Behar KL, Hyder F.
  15. 7 PubMed, Neurochem Res. 2002 Dec;27(12):1641-7. PMID: 12515317 Energy consumption by phospholipid metabolism in mammalian brain. Purdon AD, Rosenberger TA, Shetty HU, Rapoport SI.
  16. 8 PubMed, DOI: 10.1373/clinchem.2005.048611 Published May 2005 [PubMed] The Metabolic Syndrome: Requiescat in Pace, Gerald M. Reaven.
  17. 9 Clinical Chemistry, DOI: 10.1373/clinchem.2005.048611 Published May 2005 The Metabolic Syndrome: Requiescat in Pace, Gerald M. Reaven
  18. 10 The New England Journal of Medicine, N Engl J Med 2013; 369:540-548, Glucose Levels and Risk of Dementia, Paul K. Crane, M.D., et al.
  19. 11 NCBI PubMed, Am J Physiol. 1996 May;270(5 Pt 1):E746-51. Changes in cerebral blood flow and carbohydrate metabolism diuring acute hyperketonemia, S.G. Hasselbalch, et al.
  20. 12 vimeo - The ‘Holy Grail’ of Primal Health, Vimeo: Nora Gedgaudas, C.N.S., C.N.T. Health: Benefits of a Fat-Based Caloric Intake for Body and Brain.
  21. 20 PHYS.ORG, Smarter brains are blood-thirsty brains, August 30, 2016
  22. 21 The Royal Society, Fossil skulls reveal that blood flow rate to the brain increased faster than brain volume during human evolution, Roger S. Seymour, Vanya Bosiocic, Edward P. Snelling, Aug/2016

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